在好大夫网上北京天坛医院神经外科胶质瘤排名第一的主任医师江涛大夫看了MRI片子后,回复了我们的网上咨询,结论是一致的。不建议手术,“也无法彻底切除,可以考虑放化疗。”对于有何国内或国际的实验性治疗(Clinical Trials), 或者中医的结合治疗建议, 江大夫的回复是 “目前针对脑干胶质瘤有效的药物不多。最常见的治疗手段即是放疗,可以联合替莫唑胺辅助化疗,也有患者有不错的效果。中药这块,个人觉得不可靠。”
Of course, this feedback is for general information purpose and not a recommendation for the treatment, which requires much more diagnosis.
江涛大夫简介
替莫唑胺胶囊
替莫唑胺胶囊(蒂清)是治疗脑胶质瘤的口服胶囊制剂,针对性强、特异性高,可透过血脑屏障,用于治疗脑胶质瘤及转移瘤。两年多的临床观察及研究工作显示,蒂清替莫唑胺胶囊治疗脑胶质瘤效果显著,同时具有延长生存时间、提高生存质量的作用,是治疗脑胶质瘤,特别是多形性胶质母细胞瘤或间变性星形细胞瘤的一线用药。
蒂清替莫唑胺胶囊(temozolomide)是一种新型的口服二代烷化剂-咪唑四嗪类衍生物,口服后迅速吸收,具有近100%的生物利用度及广谱的抗肿瘤活性。蒂清进入体内不经肝脏代谢广泛分布于全身,并可透过血脑屏障,进入脑脊液;在中枢神经系统达到有效的药物浓度。
Temozolomide - (brand names Temodar and Temodal) is an oral alkylating agent used for the treatment of Grade IV astrocytoma — an aggressive brain tumor, also known as glioblastoma multiforme — as well as for treating melanoma, a form of skin cancer. Temozolomide is also indicated for relapsed Grade III Anaplastic Astrocytoma and not indicated for, but as of 2011[update] used to treat oligodendroglioma brain tumors in some countries, replacing the older (and less well-tolerated) PCV (Procarbazine-Lomustine-Vincristine) regimen.
Side-effects - The most common non-hematological adverse effects associated with temozolomide - nausea and vomiting. For more information: https://www.navigatingcancer.com/chemotherapy_drugs/temozolomide
Clinical trial on Temozolomide Chemotherapy (completed) - see detail at: http://clinicaltrials.gov/ct2/show/study/NCT00392171?sect=X6015